The Mesenchymal Stem Cells found in Teeth are now the most researched Stem Cells in the Scientific Literature.
Dental Stem Cell Research
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- Jaksic Karisik, M, Jović Orsini, N, Carkic, J, Lazarevic, M, Mitić, D, Jokanovic, B et al.. A Carbon-Based Nanomaterial with Dichotomous Effects: Antineoplastic on Oral Cancer Cells and Osteoinductive/Chondroinductive on Dental Pulp Stem Cells. J Funct Biomater. 2025;16 (3):. doi: 10.3390/jfb16030109. PubMed PMID:40137387 PubMed Central PMC11943258.
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- Leelasangsai, W, Thummachot, K, Thammasarnsophon, P, Srion, A, Suwanprateeb, J, Patntirapong, S et al.. Cobalt-Incorporated Hydroxyapatite Conditioned Media Promotes In Vitro Scratch Wound Healing and Mesenchymal Stem Cell Migration. J Funct Biomater. 2025;16 (3):. doi: 10.3390/jfb16030072. PubMed PMID:40137351 PubMed Central PMC11942815.
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- Mekhemar, M, Terheyden, I, Dörfer, C, Fawzy El-Sayed, K. Inflammatory Modulation of Toll-like Receptors in Periodontal Ligament Stem Cells: Implications for Periodontal Therapy. Cells. 2025;14 (6):. doi: 10.3390/cells14060432. PubMed PMID:40136681 PubMed Central PMC11941712.
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- Hu, S, Zheng, C, Jiang, P, Zhang, Q, Liu, Y, Dou, L et al.. 3D visualization of neurovascular networks in pulp-exposed rat molars using tissue clearing techniques. Odontology. 2025; :. doi: 10.1007/s10266-025-01092-7. PubMed PMID:40133600 .
- Hu, M, Fan, Z. Role and mechanisms of histone methylation in osteogenic/odontogenic differentiation of dental mesenchymal stem cells. Int J Oral Sci. 2025;17 (1):24. doi: 10.1038/s41368-025-00353-z. PubMed PMID:40133254 PubMed Central PMC11937254.
- Koike, H, Sugimura, M, Ouchi, R, Yoshimoto, Y, Manabe, I, Oishi, Y et al.. Macrophage Subpopulation Promotes Skeletal Muscle Regeneration Through HGF/MET Signaling-Mediated Skeletal Muscle Stem Cell Proliferation. Aging Cell. 2025; :e70042. doi: 10.1111/acel.70042. PubMed PMID:40132988 .
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- Wu, KY, Kearn, N, Truong, D, Choulakian, MY, Tran, SD. Advances in Regenerative Medicine, Cell Therapy, and 3D Bioprinting for Corneal, Oculoplastic, and Orbital Surgery. Adv Exp Med Biol. 2025; :. doi: 10.1007/5584_2025_855. PubMed PMID:40131704 .
- Wu, KY, Osman, RM, Esomchukwu, O, Marchand, M, Nguyen, BH, Tran, SD et al.. Advances in Regenerative Medicine, Cell Therapy, and 3D Bioprinting for Glaucoma and Retinal Diseases. Adv Exp Med Biol. 2025; :. doi: 10.1007/5584_2025_854. PubMed PMID:40131702 .
- Chen, J, Deng, L. KLF2 Promotes Osteogenic Differentiation of Human Periodontal Ligament Stem Cells by Regulating Nrf2 Expression. Int Dent J. 2025;75 (3):1554-1563. doi: 10.1016/j.identj.2025.02.019. PubMed PMID:40121852 .
- Hu, M, Zhang, Q, Xu, J, Xu, L, Xu, X, Wang, J et al.. New considerations in selecting donors for dental pulp stem cells: a pilot study. Biomed Eng Online. 2025;24 (1):37. doi: 10.1186/s12938-025-01367-8. PubMed PMID:40119437 PubMed Central PMC11929365.
- Deng, P, Huang, J, Zhang, Q, Li, Y, Li, J. Correction to: The role of EMILIN-1 in the osteo/odontogenic differentiation of dental pulp stem cells. BMC Oral Health. 2025;25 (1):419. doi: 10.1186/s12903-025-05759-z. PubMed PMID:40119372 PubMed Central PMC11929322.
- Yang, J, Weng, X, Chen, C, Pan, Y. Notoginsenoside R1 Promotes Osteogenic Differentiation of Dental Pulp Stem Cells via MAPK Pathway. Discov Med. 2025;37 (194):486-495. doi: 10.24976/Discov.Med.202537194.40. PubMed PMID:40116096 .
- Kim, J, Lee, MC, Jeon, J, Rodríguez-delaRosa, A, Endo, Y, Kim, DS et al.. Combinational regenerative inductive effect of bio-adhesive hybrid hydrogels conjugated with hiPSC-derived myofibers and its derived EVs for volumetric muscle regeneration. Bioact Mater. 2025;43 :579-602. doi: 10.1016/j.bioactmat.2024.09.013. PubMed PMID:40115877 PubMed Central PMC11923440.
- Ying, LH, Abdullah, M, Fuad, NA, Seong, LG, Azami, NH, Noor, NSM et al.. Biocompatibility of irrigation solutions to dental-derived mesenchymal stem cells in regenerative endodontic procedure: a systematic review of in vitro studies. Odontology. 2025; :. doi: 10.1007/s10266-025-01087-4. PubMed PMID:40111730 .
- Zhong, J, Zhang, Y, Lin, S, Kang, J, Hu, M, Liu, J et al.. Activin a regulates vascular formation and stabilization in direct coculture of dental pulp stem cells and endothelial cells. Int Endod J. 2025; :. doi: 10.1111/iej.14226. PubMed PMID:40106315 .
- Hermans, F, Vankelecom, H, Bronckaers, A, Lambrichts, I. Establishment of 3D Tooth Organoid Culture from Early-Postnatal Mouse Molar and Incisor. Methods Mol Biol. 2025; :. doi: 10.1007/7651_2025_623. PubMed PMID:40106152 .
- Belyaeva, A, Perepelina, K, Kuznetsova, E, Smirnova, D, Yakovleva, T, Turilova, V et al.. Generation of iPSCs line from patient with Singleton-Merten syndrome. Hum Cell. 2025;38 (3):71. doi: 10.1007/s13577-025-01203-0. PubMed PMID:40106038 .
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- Rewthamrongsris, P, Phothichailert, S, Chokechanachaisakul, U, Janjarussakul, P, Kornsuthisopon, C, Samaranayake, L et al.. Simvastatin modulates osteogenic differentiation in Stem Cells isolated from Apical Papilla. BMC Oral Health. 2025;25 (1):398. doi: 10.1186/s12903-025-05721-z. PubMed PMID:40102842 PubMed Central PMC11917056.
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- Ayyildiz, BG, Kocak, A, Bozoglan, E. The Comparison of Osteogenic Differentiation of Anodized Gradually and Non-Gradually Novel Implant Surfaces by 3D Cell Culture: An In Vitro Study. Int J Oral Maxillofac Implants. 2025;0 (0):1-31. doi: 10.11607/jomi.11079. PubMed PMID:40096517 .
- Manoharan, I, Jeya Goutham, PA, Kalaivani, M, Madhavan, H, Balaji, D, K, S et al.. Comparative Evaluation of the Effects of Calcium Hydroxide Intracanal Medicament and Antibiotic Paste on Dentin Microhardness: A Systematic Review. Cureus. 2025;17 (2):e78886. doi: 10.7759/cureus.78886. PubMed PMID:40091937 PubMed Central PMC11907672.
- Zhang, X, Yang, W, Zhu, B, Su, L, Li, H. Photobiomodulation therapy facilitates transplantation of dental pulp stem cells for spinal cord injury. Photodiagnosis Photodyn Ther. 2025; :104559. doi: 10.1016/j.pdpdt.2025.104559. PubMed PMID:40090474 .
- Sekar, Y, Ishwar, D, Tan, B, Venkatakrishnan, K. Nano biosensor unlocks tumor derived immune signals for the early detection of ovarian cancer. Biosens Bioelectron. 2025;278 :117368. doi: 10.1016/j.bios.2025.117368. PubMed PMID:40088704 .
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- Elahi, A, Duncan, W, Li, KC, Bhattacharjee, T, Coates, D. Supercritical CO2 With Enzymatic Posttreatment Enhances Mechanical and Biological Properties of Cancellous Bovine Bone Block Grafts. J Biomed Mater Res A. 2025;113 (3):e37896. doi: 10.1002/jbm.a.37896. PubMed PMID:40084482 .
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- Sui, Y, Dong, X, Tong, E, Zhao, C, Nie, R, Meng, X et al.. Artemisinin regulates cell proliferation, apoptosis, and the inflammatory response of human dental pulp stem cells through the p53 signaling pathway under LPS-induced inflammation. Int Immunopharmacol. 2025;152 :114396. doi: 10.1016/j.intimp.2025.114396. PubMed PMID:40056514 .
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